Exhausted B cells hamper immune response to HIV

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Recent studies have shown that HIV causes a vigorous and prolonged immune response that eventually leads to the exhaustion of key immune system cells--CD4+ and CD8+ T-cells--that target HIV. These tired cells become less and less able to fight the virus, and the cells' fatigue contributes to the inability of an HIV-infected person's immune system to clear the virus from the body. Now... Submitted by: hank russell | Visited 8 times | Comments 0

♦ Exhausted B cells fail to fight HIV

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Antibodies stick to HIV particles, preventing them from infecting other cells and triggering their destruction by immune cells. This antibody response starts out strong in HIV-infected individuals but eventually peters out. To find out why, scientists from the National Institute of Allergy and Infectious Diseases examined the cells that make the antibodies, known as B cells. Submitted by: guelph - Visited 4 - Comments 0 - Write first comment

♦ Immune Molecule That Plays A Powerful Role In Avoiding Organ Rejection Identified

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"This is a molecule with huge potential to regulate immune response," Dr. Anatolij Horuzsko, reproductive immunologist at the Medical College of Georgia Center for Molecular Chaperone/Radiobiology and Cancer Virology, says of HLA-G dimer. Dimer appears to be the most powerful among several known forms of HLA-G at inhibiting the immune response, researchers have found. Submitted by: hyjlmc - Visited 7 - Comments 0 - Write first comment

♦ Novel Computational Model Describes The Speed At Which HIV Escapes The Immune Response

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ScienceDaily (July 17, 2008) Researchers from Utrecht University, The Netherlands, have developed a model that illustrates how HIV evades the immune system. The study incorporates detailed interactions between a mutating virus and the immune system. HIV avoids recognition by the human immune response through the generation of viral variants called "escape mutants". Submitted by: mariasabetodo - Visited 3 - Comments 0 - Write first comment

♦ How Cells Die Determines Whether Immune System Mounts Response

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ScienceDaily (July 21, 2008) Every moment we live, cells in our bodies are dying. One type of cell death activates an immune response while another type doesn't. Now researchers at Washington University School of Medicine in St. Louis and St. Jude's Children's Research Hospital in Memphis have figured out how some dying cells signal the immune system. Submitted by: spronline - Visited 2 - Comments 0 - Write first comment

♦ Drug therapy to bolster immune system cells found effective toward childhood cancer

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Click here for more information. CINCINNATI, OH Researchers from The University of Texas M. D. Anderson Cancer Center have found a possible approach to therapy that may make cancer cells more sensitive to attack by immune system cells while making the immune system cells more powerful. The combination has the potential to treat different types of childhood cancer, including osteosarcoma... Submitted by: eXe - Visited 7 - Comments 0 - Write first comment

♦ Counting Immune Cells On A 'Protein Printboard'

1 vote	ScienceDaily (May 21, 2008) — In order to monitor how far an HIV infection has progressed, the number of immune cells – lymphocytes – must be counted. Researchers at the University of Twente have developed a method that neatly arranges the antibodies that bind to these immune cells on a ‘molecular printboard’. Submitted by: mikerocky - Visited 3 - Comments 0 - Write first comment

♦ How Vitamin A Promotes Cancer Growth ?

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The researchers found that vitamin A, when applied to breast cancer cells, triggers genes that can push stem cells embedded in a tumour to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumour growth. They showed that in cancer cells, vitamin A seems to turn on cancer stem cells... Submitted by: tehcaveman - Visited 3 - Comments 0 - Write first comment

♦ Novel computational model describes the speed at which HIV escapes the immune response

1 vote	Researchers from Utrecht University, The Netherlands, have developed a model that illustrates how HIV evades the immune system. The study, published July 18th in the open-access journal PLoS Computational Biology, incorporates detailed interactions between a mutating virus and the immune system. Submitted by: R-J - Visited 8 - Comments 0 - Write first comment

♦ Achilles Heel of HIV Uncovered

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The Achilles heel, a tiny stretch of amino acids numbered 421-433 on gp120, is now under study as a target for therapeutic intervention. The abzymes are now under development for HIV immunotherapy by infusion into blood "Unlike the changeable regions of its envelope, HIV needs at least one region that must remain constant to attach to cells. If this region changes, HIV cannot infect cells. Submitted by: wisam74us - Visited 4 - Comments 0 - Write first comment

♦ Researchers Identify Immune Cells That Block Allergic Reactions

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ScienceDaily (July 16, 2008) When it comes to allergies, both the problem and the solution are found within us. Our immune systems respond to foreign substances with an arsenal of cells. Some are programmed to "remember" invaders they've encountered in the past. Normally, anything previously identified as harmless is allowed to pass. Sometimes, however, the immune response goes awry... Submitted by: yummytork - Visited 3 - Comments 0 - Write first comment

♦ Mindfulness Meditation Slows Progression Of HIV, Study Suggests

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But the immune systems of HIV/AIDS patients face another enemy as well -stress, which can accelerate CD4 T cell declines. Now, researchers at UCLA report that the practice of mindfulness meditation stopped the decline of CD4 T cells in HIV-positive patients suffering from stress, slowing the progression of the disease. The study was just released in the online edition of the journal Brain... Submitted by: quite - Visited 8 - Comments 0 - Write first comment

♦ Predicting Acute GVHD By Gene Expression Could Improve Liver Stem Cell Transplant Outcomes

1 vote	Every moment we live, cells in our bodies are dying. One type of cell death activates an immune response while another type doesn't. Now researchers have figured out how some dying cells signal the immune system. Submitted by: 7dayFSBO - Visited 1 - Comments 0 - Write first comment

♦ Vitamin A Pushes Breast Cancer To Form Blood Vessel Cells

1 vote

ScienceDaily (July 17, 2008) Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth. Submitted by: Ariestoteles - Visited 2 - Comments 0 - Write first comment

♦ TB Posing 'Major Challenges' To HIV Treatment

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Dr Diane V. Havlir, of the University of California, San Francisco, and colleagues examined interactions between HIV and TB for HIV care programs and the framework for HIV programs to incorporate TB activities, and global progress in implementation. "As HIV care expands further, there is both an opportunity and necessity for incorporation of TB control activities into these programs... Submitted by: bingohoney - Visited 3 - Comments 0 - Write first comment

♦ Stem Cells May Treat Muscular Dystrophy

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The researchers have revealed that they derived the muscle-building stem cells from a larger pool of so-called satellite cells, which normally associate with mature muscle fibres and play a role in muscle growth and repair. They say that besides their contributions to mature muscle, the injected cells also replenished the pool of regenerative cells normally found in muscle. According to them... Submitted by: Cyrus_vtn - Visited 3 - Comments 0 - Write first comment

♦ Control switches found for immune cells that fight cancer, viral infection

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Medical science may be a significant step closer to climbing into the driver's seat of an important class of immune cells, researchers at Washington University School of Medicine in St. Louis report in Nature Immunology. The researchers showed that a single protein, HS1, enables key functions of natural killer (NK) cells, which kill early cancers and fight off viral infections. Submitted by: technolarity - Visited 0 - Comments 0 - Write first comment

♦ Nanotechnology In Food And Packaging Accepted By Consumers

1 vote	Every moment we live, cells in our bodies are dying. One type of cell death activates an immune response while another type doesn't. Now researchers have figured out how some dying cells signal the immune system. Submitted by: vanshake - Visited 0 - Comments 0 - Write first comment

♦ Adult stem cells activated in mammalian brain

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Adult stem cells originate in a different part of the brain than is commonly believed, and with proper stimulation they can produce new brain cells to replace those lost to disease or injury, a study by UC Irvine scientists has shown. Evidence strongly shows that the true stem cells in the mammalian brain are the ependymal cells that line the ventricles in the brain and spinal cord... Submitted by: kriss05 - Visited 13 - Comments 0 - Write first comment

♦ Researchers urge integrating TB into HIV care

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In resource-limited settings where tuberculosis is a major cause of mortality among HIV patients and where a multidrug-resistant TB epidemic is emerging, researchers are pressing for approaches to integrate TB prevention and treatment into HIV care and treatment. "HIV programs have no option but to address TB vigorously to save patient lives, safeguard the massive investment in HIV treatment... Submitted by: HH - Dan - Visited 4 - Comments 0 - Write first comment